abstract：:The possible molecular conformations of four structurally and biologically different lipoxins derivatives were predicted by a systematic structure tree theoretical analysis. This method takes into account the London-Van der Waals energy of interaction, the electrostatic interaction, the rotation energy of the torsiona...

journal_title：Advances in experimental medicine and biology

authors： Brasseur R,Serhan CN,Deleers M

更新日期：1988-01-01 00:00:00

abstract：:The interaction between two neuropeptides, VIP and TRH, was studied. The TRH receptor binding ability was examined using intact GH3 cells and its membrane fraction. The TRH binding ability decreased when intact cells were preincubated with VIP, forskolin or db-cAMP, but not when the membrane fraction was treated with ...

journal_title：Advances in experimental medicine and biology

authors： Ogawa N,Haba K,Hirakawa S,Mizukawa K,Tsushima T

更新日期：1988-01-01 00:00:00

abstract：:Gonadal and adrenal hormone levels appear to be linked to the stressors experienced by young adolescents. Adjustment problems were accompanied by a profile of lower gonadal steroids and higher adrenal androgen levels, primarily androstenedione. Later gonadal maturation may be a result of stress suppressing the reprodu...

journal_title：Advances in experimental medicine and biology

authors： Susman EJ,Nottelmann ED,Dorn LD,Inoff-Germain G,Chrousos GP

更新日期：1988-01-01 00:00:00

abstract：:These investigations were undertaken to elucidate whether the difference between the time courses of the isometric tension and the velocity of shortening upon releases to a given isotonic load various times during a twitch is due to a change in the kinetics of the individual cross-bridges, i.e. in the rate constants g...

journal_title：Advances in experimental medicine and biology

authors： Haugen P

更新日期：1988-01-01 00:00:00

abstract：:Permethylated N-trifluoroacetyl hexosamine containing oligosaccharide alditols are favorable for analysis by mass spectrometry. Electron impact and fast atom bombardment mass spectra of these derivatives are characterized by strong primary and secondary fragments in which a positive charge is localized on the N-triflu...

journal_title：Advances in experimental medicine and biology

authors： Nilsson B

更新日期：1988-01-01 00:00:00

abstract：:The effect of r-TNF on T. musculi is complex. When trypanosomes are incubated in culture with this monokine, TNF exerts a direct anti-trypanosomal effect (Table 3). Similarly, if mice are treated with TNF during the later stages of infection, after the parasitaemia has stabilized, it hastens the elimination of the try...

journal_title：Advances in experimental medicine and biology

authors： Kongshavn PA,Ghadirian E

更新日期：1988-01-01 00:00:00

abstract：:In an experimental and clinical study a significant reduction of the postoperative edema after extracorporeal extremity perfusion under addition of Aprotinin was observed. Together with reduction of edema usually expected complications like pain and peripheral nerve damage could be reduced significantly. Preliminary, ...

journal_title：Advances in experimental medicine and biology

authors： Walther H,Müller H,Aigner KR

更新日期：1988-01-01 00:00:00

abstract：:This paper suggests the molecular mechanism in muscle whereby some of the delta G of ATP hydrolysis is converted to mechanical work. There is good evidence for thinking that all mechanical, thermal, and chemical observations of muscle result from the summated, repetitive, operation of identical unitary "engines". Such...

journal_title：Advances in experimental medicine and biology

authors： Morales MF

更新日期：1988-01-01 00:00:00

abstract：:Fluorodeoxyuridylate (FdUMP) and thymidylate synthase (TS) are one of the better understood systems of drug-target interaction in cancer chemotherapy. Isolation and characterization of TS (initially from Lactobacillus casei and later from a variety of other sources), cloning and sequencing of the gene, determination o...

journal_title：Advances in experimental medicine and biology

authors： Huennekens FM,Montejano YD,Vitols KS

更新日期：1988-01-01 00:00:00

abstract：:Infection by an attenuated replication-competent murine retrovirus (Friend leukemia virus-FLV4), but not other non-transforming retroviruses, stimulated rejection of transplantable thymomas (RL-cell line) and subsequent tumor immunity in syngeneic mouse recipients. FLV-infected RL-cells (RL-FLV) were unaltered in thei...

journal_title：Advances in experimental medicine and biology

authors： Thiel K,Genovesi EV,Iglehart JD,Bolognesi DP,Weinhold KJ

更新日期：1988-01-01 00:00:00

abstract：:Employees in a seafood factory developed high titers of serum IgE and IgG antibody to antigens from prawn (N. norvegicus) which were aerosolized during processing. Significant serum IgE antibody titers occurred only among those subjects with occupation-related respiratory symptoms, and this serological parameter may b...

journal_title：Advances in experimental medicine and biology

authors： McSharry C,Wilkinson PC

更新日期：1987-01-01 00:00:00

abstract：:Cross sectional segments were removed from the uteri of pregnant and pseudopregnant mice and incubated in vitro with labeled amino acids. Proteins that were synthesized and secreted by these explants were separated by two-dimensional polyacrylamide gel electrophoresis and localized by fluorography. As expected, the ov...

journal_title：Advances in experimental medicine and biology

authors： Weitlauf HM

更新日期：1987-01-01 00:00:00

abstract：:The etiology of motor neuron disease (MND) is unknown and treatment is limited to measures which sustain the patient. We review selected epidemiologic studies searching for a pattern in the clinical expression of MND which may reflect the operation of the underlying cause. Recognition of patterns of occurrence of MND ...

journal_title：Advances in experimental medicine and biology

authors： Mulder DW,Kurland LT

更新日期：1987-01-01 00:00:00

abstract：:Screening of recombinant cosmid and phage libraries with a rabbit C alpha cDNA probe has identified a total of seven C alpha genes organized into two clusters; one cluster contains four genes and the other cluster, three genes. Southern blot analysis of genomic DNA indicates that the rabbit genome contains a minimum o...

journal_title：Advances in experimental medicine and biology

authors： Burnett RC,Schneiderman RD,Knight KL

更新日期：1987-01-01 00:00:00

abstract：:PAs are intracellular regulators of growth and anabolic processes. Toxic properties of PAs are conferred according to the increasing number of cationic charges. In uremia, PA accumulation occurs both in and outside the cell. Decreased PA synthesis and blunted PA pathway responses suggest PAs may participate in cellula...

journal_title：Advances in experimental medicine and biology

authors： Campbell RA

更新日期：1987-01-01 00:00:00

abstract：:We studied the relationship between serum selenium (Se) and left ventricular performance in 33 patients on maintenance haemodialysis. Low serum Se was frequent. However, there were no significant differences in echocardiographic indices of left ventricular function between patients with serum Se less than 0.9 umol/l a...

journal_title：Advances in experimental medicine and biology

authors： Maher ER,Sampson B,Curtis JR

更新日期：1987-01-01 00:00:00

abstract：:We have described our current criteria for selecting those patients with acute V T-E who merit long-term protection, for accomplishing the acute to long-term transition efficiently and for deciding when such protection can be interrupted. Naturally, in individual patients, special circumstances may exist which alter t...

journal_title：Advances in experimental medicine and biology

authors： Moser KM

更新日期：1987-01-01 00:00:00

abstract：:A comprehensive synthetic approach was employed to identify the continuous regions of T-cell recognition on the alpha-chain of Torpedo californica acetylcholine receptor (AChR). Eighteen synthetic consecutive overlapping peptides, of uniform size and overlaps, that spanned the entire extracellular part (residues 1-210...

journal_title：Advances in experimental medicine and biology

authors： Yokoi T,Mulac-Jericevic B,Atassi MZ

更新日期：1987-01-01 00:00:00

abstract：:Transcutaneous PO2 measurements at 37 degrees C can recognize and quantify diabetic microangiopathy if suitable stimulation tests are used. The following parameters are of practical importance: resting PO2, postocclusive PO2, rubefacient-induced PO2 and 45 degrees C heating PO2. Patients with diabetic microangiopathy ...

journal_title：Advances in experimental medicine and biology

authors： Weindorf N,Schultz-Ehrenburg U,Altmeyer P

更新日期：1987-01-01 00:00:00

abstract：:Intermittent measurement of blood pressure (BP) is frequently performed in newborn babies under intensive care using an inflatable cuff encircling either the arm or leg. This paper describes work aimed at achieving continuous beat-by-beat measurement of the arterial pressure waveform by means of a finger cuff, the pre...

journal_title：Advances in experimental medicine and biology

authors： Rolfe P,Kanjilal PP,Murphy C,Burton PJ

更新日期：1987-01-01 00:00:00

abstract：:213 paired tcpO2/paO2-data and 186 paired tcSO2/SaO2-data measured in 25 newborns (10 term, 15 prematures) were compared. The correlation coefficient for tcpO2/paO2 was 0.796, for tcSO2/SaO2 0.944. Sensitivity for discriminating between normo- and hypoxemia (paO2 less than 50 torr) was 82% for the tcpO2- and 88% for t...

journal_title：Advances in experimental medicine and biology

authors： Bossi E,Meister B,Pfenninger J

更新日期：1987-01-01 00:00:00

abstract：:The incidence and severity of retinopathy of prematurity (ROP) were studied in 561 survivors of low birth weight infants (LBWIs) weighing under 2,000g. They were the survivors out of 604 LBWIs admitted to Okayama National Hospital during the five years from January 1981 to December 1985. The tcPO2 of all the LBWIs on ...

journal_title：Advances in experimental medicine and biology

authors： Yamanouchi I,Igarashi I,Ouchi E

更新日期：1987-01-01 00:00:00

abstract：:Thermal clearance curves following termination of ultrasound-induced hyperthermia in human mammary carcinomas implanted into the flanks of nude rats were studied. They were found to be monoexponential in form, both with and without blood flow. From the difference between the inverse time constants with and without flo...

journal_title：Advances in experimental medicine and biology

authors： Braun RD,Goldstick TK,Kluge M,Kallinowski F,Vaupel P,George SC

更新日期：1987-01-01 00:00:00

abstract：:The Adair four-step kinetic model for the reactions of haemoglobin and oxygen recognizes five haemoglobin species, corresponding to deoxyhaemoglobin and one species for each level of oxygenation of the four haem groups. Thus, an oxygen transport problem involves a system of five simultaneous non-linear partial differe...

journal_title：Advances in experimental medicine and biology

authors： Yap EW,Hellums JD

更新日期：1987-01-01 00:00:00

abstract：:The relation of transcutaneous pO2 (tcpO2) and cutaneous blood flow (CBF) was measured on the forearm of 19 healthy volunteers by use of a tcpO2 electrode heated to 45 degrees C. CBF was estimated indirectly from the heating power of the electrode (HP) and with a 8 MHz bidirectional ultrasonic probe by Doppler shift i...

journal_title：Advances in experimental medicine and biology

authors： Steinacker JM,Spittelmeister W,Wodick R

更新日期：1987-01-01 00:00:00

abstract：:According to our present knowledge hypometabolism and hypothermia in uremia are most probably due to direct actions of toxic substances at the cellular level. A cardiovascular etiology seems less possible. A similar reduction of oxygen consumption as observed in uremia can be produced by 5 mg/kg body wt. indole i.p. A...

journal_title：Advances in experimental medicine and biology

authors： Hohenegger M,Echsel H,Vermes M,Raneburger H

更新日期：1987-01-01 00:00:00

abstract：:Feline infectious peritonitis (FIP) is caused by one of several strains of feline coronaviruses which are grouped into 2 general types of viruses. Infection of cats with FIP virus results in production of serum antibodies which may be protective in conjunction with cell mediated immunity, may provided no protection at...

journal_title：Advances in experimental medicine and biology

authors： Scott FW

更新日期：1987-01-01 00:00:00

abstract：:Acidification of endocytic compartments occurs within 2-3 minutes following internalization. In CHO cells, three kinetically and morphologically distinct endocytic or recycling compartments can be identified. Measurements of the pH in these compartments show that the acidity of the compartments is regulated independen...

journal_title：Advances in experimental medicine and biology

authors： Maxfield FR,Yamashiro DJ

更新日期：1987-01-01 00:00:00

abstract：:The primary trihydroxy bile acid, cholate, both free and conjugated, is nontoxic in cultured human lymphoblastoid cells incubated in vitro. The primary dihydroxy bile acid, chenodeoxycholate, was more toxic at high concentrations than at low concentrations, but conjugation with taurine reversed it. The free secondary ...

journal_title：Advances in experimental medicine and biology

authors： Gaull GE,Wright CE

更新日期：1987-01-01 00:00:00

abstract：:Our studies revealed that virus induced demyelination as well as human inflammatory demyelination involves upregulation of class I MHC genes and surface expression of antigens encoded by these genes. Induction involves the action of an intermediate soluble factor/s which is at present unknown. These findings suggest t...

journal_title：Advances in experimental medicine and biology

authors： Lavi E,Suzumura A,Lampson LA,Siegel RM,Murasko DM,Silberberg DH,Weiss SR

更新日期：1987-01-01 00:00:00

abstract：:cDNA clones mapping within the first 2601 bases of the 3' end of the TGEV genome were sequenced completely or in part by the method of Maxam and Gilbert and open reading frames were examined. One reading frame yielding a protein having properties of the matrix (M) protein was identified. It is positioned at the immedi...

journal_title：Advances in experimental medicine and biology

authors： Kapke PA,Tung FY,Brian DA,Woods RD,Wesley R

更新日期：1987-01-01 00:00:00

abstract：:We have examined the question of how hormones regulate the biosynthesis of gonadotropins. In particular we have studied the effects of gonadal sex steroid hormones on the regulation of LH subunit gene expression to determine whether they may occur at the pre-translational level. Success in the molecular cloning of cDN...

journal_title：Advances in experimental medicine and biology

authors： Chin WW,Gharib SD

更新日期：1986-01-01 00:00:00

abstract：:Raw soya flour (RSF) feeding to rats produces pancreatic hypertrophy and hyperplasia, and, if sufficiently prolonged, the spontaneous development of pancreatic neoplasms and the potentiation of pancreatic carcinogens. With continuous exposure to RSF the threshold dose for pancreatic growth is approximately 20% RSF, bu...

journal_title：Advances in experimental medicine and biology

authors： Morgan RG,Crass RA,Oates PS

更新日期：1986-01-01 00:00:00

abstract：:The various reactions involved in the formation and actions of biological reactive intermediates of AFB1 are undoubtedly common to the wide variety of mycotoxins. The structural diversity of mycotoxins and their widespread occurrence in nature has made them a significant class of model environmental toxicants for mode...

journal_title：Advances in experimental medicine and biology

authors： Hsieh DP

更新日期：1986-01-01 00:00:00

abstract：:In this paper we report the effect of sulfatides on rate constants of Factor XII activation by kallikrein and its isolated light chain. In free solution kallikrein and the light chain were equally effective in activating Factor XII and both enzymes had their pH optimum at pH 7.0 (k1 = 1.6 X 10(3) M-1 s-1). Sulfatides ...

journal_title：Advances in experimental medicine and biology

authors： Rosing J,Tans G,Griffin JH

更新日期：1986-01-01 00:00:00

abstract：:We have demonstrated that kinins are generated following nasal challenge with allergen of allergic (5.6 +/- 0.17 ng/m-), but not nonallergic (0.04 +/- .02 ng/ml), individuals (n = 8 in each case). The presence of kinin was highly correlated with that of histamine and TAME-esterase activity and with clinical symptoms (...

journal_title：Advances in experimental medicine and biology

authors： Proud D,Naclerio RM,Togias AG,Kagey-Sobotka A,Adkinson NF Jr,Norman PA,Lichtenstein LM

更新日期：1986-01-01 00:00:00

abstract：:Further to explore the functions of carboxypeptidase N (CPN) in vivo, we undertook two studies to find CPN inhibitors of high potency and relatively long duration of action. In each study we examined for inhibition of hydrolysis of [3H]benzoyl-Ala-Arg using pure bovine serum CPN or human serum. In the first such study...

journal_title：Advances in experimental medicine and biology

authors： Fisher GH,Ryan JW,Chung A,Plumer TH Jr

更新日期：1986-01-01 00:00:00

abstract：:Retinoids clearly show both prophylactic and therapeutic effects against many kinds of neoplasm. Vitamin A deficiency and vitamin A excess, which are very different states clinically and metabolically, should be separately considered relative to carcinogenesis. The anticancer effects of retinoids and related compounds...

journal_title：Advances in experimental medicine and biology

authors： Olson JA

更新日期：1986-01-01 00:00:00

abstract：:Review of the literature of the past 40 years on tyrosine and its toxicity shows that no direct link between this aromatic amino acid and carcinogenesis has been well established. Ten years ago, studies of tyrosine toxicity in mice suggested the formation of an epoxide adduction product presumably derived from tyrosin...

journal_title：Advances in experimental medicine and biology

authors： Laberge C,Lescault A,Tanguay RM

更新日期：1986-01-01 00:00:00

abstract：:Articular cartilage contains any ectoenzyme activity, NTP-PPH, which is capable of generating PPi from NTP substrates. The PPi generated is from the cleavage of the alpha-beta pyrophosphate bond of NTP and does not result from the effects of NTP catabolites. NTP-PPH activity is expressed on human skin fibroblasts in c...

journal_title：Advances in experimental medicine and biology

authors： Wortmann RL,Ryan LM,Karas B,McCarthy DJ

更新日期：1986-01-01 00:00:00